Document Details
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Document Type |
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Thesis |
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Document Title |
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POSSIBLE COMBINED EFFECT OF PERINDOPRIL AND AZILSARTAN IN AN EXPERIMENTAL MODEL OF DEMENTIA IN RATS. التأثير المحتمل لعقاري البرندوبرل والأزلسارتان في نموذج تجريبي للخرف في الجرذان |
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Subject |
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Faculty of medicine |
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Document Language |
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Arabic |
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Abstract |
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Background: Several studies have proven a correlation of renin-angiotensin system with neurodegenerative diseases such Alzheimer's disease. Alzheimer's is associated with memory and cognitive dysfunction .The present study was conducted to investigate whether perindopril and azilsartan combination have neuroprotective effect against aluminum chloride-induced cognitive impairment in rats than either alone.
Methodology: Fifty-four male albino Westar rats were used in this study. Alzheimer's was induced by daily administration of aluminum chloride (AlCl3) (100 mg/kg), groups of rats were categorized into nine groups. Normal control (saline), vehicle received carboxymethyl cellulose (CMC), positive control (Alcl3, 100 mg/kg), perindopril groups (0.5 and 1mg /kg/day) plus (Alcl3, 100 mg/kg), azilsartan groups ( 3.5 and 7 mg/kg/day) plus (Alcl3, 100 mg/kg) and combined groups 1&2 [(perindopril 0.5 mg/kg + azilsartan 3.5 mg/kg ) and (perindopril 1 mg/kg + azilsartan 7 mg/kg)], respectively, plus (Alcl3, 100 mg/kg). The duration of treatment was 60 days. The behavioral test was used to assess cognitive function, followed by estimation levels of beta-amyloid-42 (Aβ-42), acetylcholine esterase (AChE), malondialdehyde (MDA), tumour necrosis factor alpha (TNF-α), nitric oxide (NO) in the hippocampus by ELISA kits and histological examination of different hippocampal regions.
Results and discussion: Chronic treatment with perindopril and azilsartan either alone or in combination significantly alleviated cognitive decline evaluated by the Y-maze test with a significant decrease in the hippocampal levels of Aβ-42, AChE, MDA, and TNF-α versus non treated control (positive control). Furthermore, most hippocampus histopathological changes were improved.
Conclusion and recommendations: based on behavioral, biochemical, and histopathological findings of the present study, it is concluded that this study showed neuroprotective effect of ACEIs and ARBs either combined or alone. |
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Supervisor |
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Prof. Dr. Mai A. Alim A. Sattar |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1441 AH
2020 AD |
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Co-Supervisor |
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Dr. Fatemah Omar Kamel |
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Added Date |
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Friday, June 12, 2020 |
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Researchers
| يحيى محمد الزهراني | Alzahrani, Yahya Mohammed | Researcher | Master | |
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