Document Details

Document Type : Thesis 
Document Title :
Worst Pattern of Invasion and other Histopathological Features In Oral Cancer As Determinants Of Prognosis And Survival Rate
أسوأ نمط من الغزو والسمات المرضية الأخرى في سرطان الفم كمحددات للتنبؤ ومعدل البقاء.
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Background: Oral cavity squamous cell carcinoma (OCSCC) is a well-known malignancy of the head and neck. Multiple studies on Patients with low-stage oral cancer documented that these patients develop local recurrence and/or regional lymph node metastasis, and disease-related mortality. which means that early stage oral cancer doesn’t always predict good prognosis. Objectives: 1- To determine the efficacy of using worst pattern of invasion and other histopathological features as prognostic factors in oral cancer. 2- To analyze the impact of resection margins status and histopathological prognosticators on local recurrence and overall survival for patients with oral squamous cell carcinoma. Methods: A retrospective cohort study was conducted by reviewing the charts of 63 patients with Oral cavity SCCs treated with primary surgery at the king abdulaziz University hospital, from 2012 to 2019. pathology slides from their resection specimens were reviewed by an author and an experienced pathologist. Associations between histopathological factors (differentiation, stage, lymphovascular invasion, perineural invasion, WPOI, and surgical margin) and local recurrence (LR) or disease-free survival (DFS) were evaluated. Kaplan-Meier analysis was performed for disease progression and survival. Log-rank test for equality of survivor functions was performed, adjusted for potential confounders. Results: Univariate analysis identified WPOI, and perineural invasion, whereas multivariate analysis identified WPOI as predictive factors for LR., as predictive factors for DFS. Kaplan-Meier analysis for disease progression and survival. Log-rank test for equality of survivor functions was performed identified WPOI and PNI as predictive factors for disease free survival. Conclusion: We demonstrate that worst pattern of invasion (WPOI) and perineural invasion (PNI) are major independent prognosticators not only for local tumor control, but also for disease free survival. 
Supervisor : Dr. Hani Marzouki 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Added Date : Friday, June 12, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Afnan بخاريbukhari, أفنان ResearcherMaster 

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