Document Details

Document Type : Thesis 
Document Title :
THE LEVEL OF SIRT1 AND SIRT3 GENES EXPRESSION IN BREAST CANCER PATIENTS BLOOD SAMPLES
مستوى التعبير الجيني للـ SIRT1 and SIRT3 في عينات دم مرضى سرطان الثدي
 
Subject : Faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : The Level of SIRT1 and SIRT3 Gene Expressions in Breast Cancer Patients’ Blood Samples By Mahliyyah Mohammed A-Jahdali Abstract (English) Breast cancer (BC) is one of the leading causes of cancer-related death among women worldwide. Its prevention remains challenging in medical and research fields around the world. In particular, stem cells and some other genes have been found to be involved in BC detection and drug-resistant mechanisms. Currently, more therapeutic options have become available to fit each patient case, while patients quality of life progresses by ways of biological prevention. SIRT1 and SIRT3 are members of the Sirtuin (SIRT) family that play a major role in sensing cellular stress response. Stress can cause genome instability, which is present in nearly all solid tumors. The aim of this study is to detect the changes in SIRT1 and SIRT3 gene expressions in BC patient’s blood samples. SIRT1 and SIRT3 gene expressions were evaluated by qPCR, in 38 non-diabetic female patients; 25 diagnosed as breast malignant while 13 were non-malignant which was considered as a control group. The patients’ information and clinicopathological data were collected together with the blood samples from King Abdul-Aziz University Hospital. No significant difference was detected between the groups in BMI, waist/hip ratio, age and other personal characteristics. Our results show a weak significant decrease in SIRT1 (p=0 .057); however, SIRT3 demonstrated a significant increase (p= 0.034) in BC compared to the control group. This increase in SIRT3 expressions were associated with married patients and high number of miscarriages (>2). Furthermore, in association with clinicopathological characteristics, SIRT3s up-regulation was highly significant with respect to tumor size. In conclusion, SIRT3 may have a potential role in breast cancer detection and therapeutic targeting. 
Supervisor : Dr. Kulthum Al-Saqqaf 
Thesis Type : Master Thesis 
Publishing Year : 1442 AH
2021 AD 
Added Date : Saturday, June 5, 2021 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محلية محمد الجحدليALJahdali, Mahliyah MohammedResearcherMaster 

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