Document Details

Document Type : Thesis 
Document Title :
A RETROSPECTIVE STUDY OF COMMON BACTERIAL ISOLATES AND THEIR ANTIMICROBIAL SUSCEPTIBILITY PATTERN FROM PATIENTS IN A TERTIARY CARE HOSPITAL IN JAZAN, KINGDOM OF SAUDI ARABIA
دراسة استعادية للعزلات البكتيرية الشائعة ونمط حساسيتها للمضادات الحيوية من المرضى في مستشفى من مستوى الرعاية الثالثة بمدينة جازان، المملكة العربية السعودية
 
Subject : Faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : Background: The epidemiological data from a given location are useful for antimicrobial therapy. This study was carried out to find new insight regarding the prevalence of drug-resistance in relation to patient demographics among clinically isolated bacteria from King Fahad Central Hospital in Jazan in the southern region of Saudi Arabia. Methods: This is one-year retrospective study between 1st January till 31st December 2018 using previous positive bacterial cultures results for bacterial identification of clinically isolated bacteria, antibiotic susceptibility testing and patient demographic information retrieved from microbiology laboratory results data base and statistics files from infection control department. Ethically approved consent was obtained for this study from the Ministry of Health Directorate of Jazan Health Affairs. Results: In our study it was noted that male infected patients (57.3%) were more than female patients (42.5%) and age group >19 to 39 years old (young adults) were more prone to common bacterial infections as well as multi-drug resistant (MDR) organisms. Also, majority of clinically isolated microorganisms were from blood culture samples which were received from intensive care unit which yielded predominantly Gram-negative bacteria and most common isolates were Klebsiella pneumoniae followed by Pseudomonas aeruginosa. Among 649 Escherichia coli isolates, 53.1% were found MDR and 57% of the isolates were resistant to both amoxicillin-clavulanate and cefepime. Five hundred and ninety-eight (42.5%) of Klebsiella species isolates were MDR and 52% and 50% of the isolates were resistant to ceftriaxone and ceftazidime, respectively. Of 208 Acinetobacter baumannii isolates 35% were MDR and all isolates were resistant to aztreonam. Among 486 Staphylococcus aureus isolates, 63.8% were found MDR and methicillin-resistance was observed in 66% of the isolates. Conclusion & Recommendations: This study provides information on the patterns of antimicrobial-resistance in isolates of Escherichia coli strains, Klebsiella strains and other bacterial pathogens in Jazan city in the southern region of the Kingdom of Saudi Arabia. The study is important in terms of knowing the prevalence of methicillin-resistant Staphylococcus aureus and other multidrug-resistant (MDR) isolates in the region. The important results of this study will also be useful to medical microbiologists and clinicians in recommending the best antimicrobial drug based on patterns of resistance to treat different infections in Jazan region, Saudi Arabia. 
Supervisor : Dr. Abdulaziz Omar Bamarouf 
Thesis Type : Master Thesis 
Publishing Year : 1443 AH
2022 AD 
Added Date : Tuesday, March 15, 2022 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أحمد محمد دغريريDaghriri, Ahmed MohammedResearcherMaster 

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