Document Details
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Document Type |
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Thesis |
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Document Title |
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Assessment of Renal Function in Sickle Cell Disorders تقييم وظائف الكلى في مرضى الأنيميا المنجلية |
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Subject |
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Faculty of Applied Medical Sciences |
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Document Language |
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Arabic |
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Abstract |
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Background: Sickle cell anemia (SCA) is generally caused by a genetic mutation that causes a structural change in hemoglobin, which leads to forming a sickle shape of RBCs. This sickle shape leads to the destruction of body organs, the kidney is one of these organs.
Aim: This study aimed to assess the hematological tests and kidney function in patients with SCA by comparing them to a healthy control group.
Method: 172 patients with SCA, 70 sickle cell traits, and 91 healthy control were recruited for this cross-sectional study. Following informed consent, 5 mL of two venous blood samples were collected for the hematological test, renal function tests, and electrolytes. The statistical analysis was done by using SPSS version 25, and the comparison was followed by a T-test where p less than 0.05 is considered significant.
Result: The results of this study showed that HbS was the main type among sickle cell anemia cases (67.4%), followed by HbA1 (22.4%). Patients with SCD had higher WBCs counts, MCH, MCHC, RDW%, and platelets count, but had lower values for RBCs count, hemoglobin, and hematocrit. V. Na+ and K+ levels were significantly higher (p less than 0.05) in patients with SCD compared to the healthy control group. However, there were non-significant differences (p greater than 0.05) in the levels of urea between SCD cases and the healthy controls. Creatinine was significantly lower (p less than 0.05) in SCD compared to healthy control. On the impact type of SCD (HbSS and HbAS), there was a non-significant difference (p greater than 0.05) in the levels of Na+, K+, and urea among the two groups, but it was significantly lower (p less than 0.05) in the level of creatinine for the HbSS group.
Conclusions: The study concluded that patients with SCD tend to have impaired kidney function. As they should receive health education regarding their general health status and how to avoid renal impairment. |
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Supervisor |
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Dr. Talal Hussein Qadah |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1443 AH
2022 AD |
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Added Date |
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Monday, January 16, 2023 |
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Researchers
| أنور عبده رفاعي | Refaei, Anwar Abdu | Researcher | Master | |
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