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Document Type |
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Thesis |
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Document Title |
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Association of ABO Blood Groups and P1 Antigen with the Development of Type II Diabetes Mellitus علاقة فصائل الدم ABO ومستضدP1 مع تطور مرض الداء السكري من النوع الثاني |
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Subject |
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Faculty of Applied Medical Sciences |
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Document Language |
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Arabic |
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Abstract |
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Introduction: The Middle East region is predicted to have one of the highest prevalence of type II diabetes mellitus (TIIDM) in the world due to rapid economic development. Saudi Arabia has been ranked by the World Health Organization (WHO) as the second highest diabetes prevalence in the Middle East. The prevalence of TIIDM in Saudi Arabia is 32.8% in 2015, and the predicted prevalence will be increase up to 45.36% in 2030. The predisposition of TIIDM has been connected to several aspects such as obesity, lack of exercise, genetic, and environmental factors having their role in its genetic expression. However, this shows that Diabetes Mellitus (DM) is rapidly increasing and becoming the major cause of medical complications and death.
Aim: Find the association between ABO blood groups and P1 antigen with the development of TIIDM.
Methods: Case control study, included 150 TIIDM patients and 120 non- diabetic control from both International Medical Center (IMC) and King Abdul-Aziz University Hospital (KAUH).
Results: All the data tested statistically by Chi-square. Blood group B was significantly more common in TIIDM (19% vs.10%), whereas blood group O was significantly more common in non-diabetic control 56%. Blood group A has similar distribution in both. B blood group is the only blood group showed statistically significant (χ²= 4.509, p value = 0.0337). P1 antigen distribution showed statistically significant difference of P1 antigen positive in TIIDM, (χ²= 4.049, p value= 0.0441), while Rhesus (Rh) blood group distribution showed no significancy.
The association between Rh blood group and P1 antigen in type II diabetic patients were tested and showed no association at p<0.05.
Conclusion: There is a positive association between blood group B and P1 antigen with development of TIIDM. No association between Rh and development of TIIDM and, no association between Rh blood group and P1 antigen in TIIDM patients.
Key words: ABO antigens, P1 antigen, Diabetes Mellitus, Association, Saudi Arabia |
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Supervisor |
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Dr. Nora Hakami |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1444 AH
2022 AD |
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Added Date |
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Monday, February 27, 2023 |
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Researchers
| شروق ابراهيم السيد | Al-Sayed, Shroug Ibrahim | Researcher | Master | |
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