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Document Type |
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Thesis |
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Document Title |
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Cataract, the most common cause of visual loss and blindness worldwide. This study provides a systemic review of the recent findings on the association of vitamin D (Vit-D), Vitamin B12 (Vit- B12) and their possible role in preventing cataract in senile (S) and diabetes mellitus (DM) patients. العلاقة بين تركيزات فيتامين د وفيتامين ب 12 في مرضى إعتام عدسة العين (الشيخوخة مقابل السكري) |
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Subject |
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Faculty of Applied Medical Sciences |
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Document Language |
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Arabic |
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Abstract |
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Objective: To investigate the role of Vit-D and Vit-B12 on cataract and eye health. secondly, testing the connection between serum level of Vit-D and Vit-B12 in cataract (S) vs (DM) patients. To evaluate and analyze cataract occurrence regarding Vit-D and Vit-B12 levels with other risk factors. Finally, to evaluate lens opacities pre and post treatment with Vit-D and Vit-B12 related to age and visual acuity loss in both (S) and (DM) cataract patients.
Methods: Select prospective case control to study the effect of Vit-D and Vit B12 on (S) caused by age and (DM) cataract patients, compare between these two groups. This study prospectively enrolled a total of 50 participants, 25 with senile cataract and 25 with diabetic cataract. Measuring 25-hydroxy Vit-D and Vit-B12 concentrations among participants. The Cobas e 411 device was used from the international company Roche, and it is considered one of the most modern devices in the world to test vitamin D and B12, which is based on Electrochemiluminescence (ECL) technology.The participant is then taken to an ophthalmology clinic where an optical coherence tomography device is used to take an image of the eye. The therapeutic supplement consisting of vitamin D 50,000 IU once a week and vitamin B12 at a dose of 2.4 micrograms daily for 3 months was used. Analyses were performed using SPSS (statistical package for the social sciences).
Results: (S) cataract patients’ group were greatly benefited by the combination therapy of Vit-D and Vit-B12 reached 28.5±1.50 ng/ml and 521.1±21.10 pg/ml, respectively, on the contrary the diabetic cataract patient group reached (21.5±1.00 ng/ml and 197.2±7.20)pg/ml, respectively. There was no significant difference between the age, body mass index (BMI), the mean of Vit-D pre-treatments and mean values of Hemoglobin A1C of both (S) and (DM) cataract patients. There was difference between the values of Vit-B12 and glucose levels in both (S) and (DM) cataract patients (p.value < 0.05) .
Conclusion: This study showed that (DM) cataract group were showing the lower response to Vit-B12 level and ocular health compared to (S) cataract patient group.
Keywords: Cataract, Senile, Diabetes Mellitus, Vitamins. |
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Supervisor |
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Dr. Marwa Ma'shi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1445 AH
2023 AD |
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Added Date |
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Wednesday, October 4, 2023 |
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Researchers
| علي شويل الأسمري | Al-Asmari, Ali Shawil | Researcher | Master | |
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