Document Details

Document Type : Thesis 
Document Title :
ANTIBACTERIAL EFFECT OF SILVER NANOPARTICLES IN STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA
التأثير المضاد للبكتيريا لجسيمات الفضة النانوية على بكتيريا المكورات العنقودية الدهبية والزائفة الزنجارية
 
Subject : Faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : Background The demand to use alternative antimicrobials had been rising due the concern of many bacterial pathogens acquiring resistance to multiple antimicrobial agents. One of them by using silver nanoparticles which has been proven to inhibit microbial growth in medically important Gram-negative and Gram-positive bacteria. This study aims to investigate the in-vitro effects and further to elucidate bacteriostatic and bactericidal concentrations of silver nanoparticles against susceptible and multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa clinical isolates. Methods Agar well diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) in-vitro methods were used to measure the inhibitory and bactericidal concentrations of sliver nanoparticles against bacterial strains. Results Ten methicillin-susceptible Staphylococcus aureus (MSSA) strains showed low MIC and MBC (1.6µg/mL and 3.2µg/mL respectively). While methicillin-resistant Staphylococcus aureus (MRSA) strains showed higher results with 3.2µg/mL for MIC and 6.4µg/mL for MBC. Moreover, in case of Pseudomonas aeruginosa strains, both drug-susceptible Pseudomonas aeruginosa (DSPA) and drug-resistant Pseudomonas aeruginosa (DRPA) showed similar results with 6.4µg/mL for MIC and 12.8 µg/mL for MBC. Conclusion & Recommendations Silver nanoparticles could be a potential therapeutic agent for the treatment of a wide spectrum of diseases caused by susceptible and multi-drug resistant medically important Staphylococcus aureus and Pseudomonas aeruginosa bacterial strains. 
Supervisor : Dr. Abdulaziz Bamarouf 
Thesis Type : Master Thesis 
Publishing Year : 1445 AH
2023 AD 
Added Date : Wednesday, October 25, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سوسن عبدالله باعطاBaata, Sawsan AbdullahResearcherMaster 

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